Detection of pyrrolidone carboxylic acid

Detection of pyrrolidone carboxylic acid.

Prediction of Protein Modification Sites of Pyrrolidone Carboxylic Acid Using mRMR Feature Selection and Analysis

Pyrrolidone carboxylic acid (PCA) is formed during a common post-translational modification (PTM) of extracellular and multi-pass membrane proteins. In this study, we developed a new predictor to predict the modification sites of PCA based on maximum relevance minimum redundancy (mRMR) and incremental feature selection (IFS). We incorporated 727 features that belonged to 7 kinds of protein prop...

Regulatory responses to an oral D-glutamate load: formation of D-pyrrolidone carboxylic acid in humans.

Previously published studies have shown D-glutamate to be the most potent natural inhibitor of glutathione synthesis known, yet how D-glutamate is handled in humans is unknown. Therefore, we administered an oral D-glutamate load to four healthy volunteers and monitored the plasma D-glutamate concentration and excretion over a 3-h postload period. Compared with time controls, the plasma D-glutam...

Metabolism of I-pyrrolidone Carboxylic Acid and Its Stability to Acids and Alkalies.*

In the study of the physiology of the amino-acids and their derivatives the cyclic compounds always engage attention because presumably the formation or disruption of ring structures requires special processes. No doubt there is considerable reason for assuming that such should be the case with homocyclic structures where there is union of carbon with carbon, but then evidence has been accumula...

[N-Methyl-2-pyrrolidone][C1-C4 carboxylic acid]: a novel solvent system with exceptional lignin solubility.

Novel solvent systems composed of N-methyl-2-pyrrolidone and C1-C4 carboxylic acid exhibit unique physicochemical properties, e.g. large polarity, low viscosity and excellent hydrogen bonding capacity, which have demonstrated excellent lignin solubility that outperforms conventional solvents and ionic liquids.